Fidaxomicin

Administration

• Type: Macrolide antibiotic
• Dosage Forms:
• Routes of Administration: PO
• Common Trade Names:

Adult Dosing

• C. diff diarrhea: 200mg PO BID x 10d

Indications by Disease

Disease	Dose	Context
Clostridium difficile	200 mg PO two times daily for 10 days	Non-Severe
Clostridium difficile	200 mg PO two times daily for 10 days	Severe

Pediatric Dosing

Safety/efficacy not established

Indications by Disease

Disease	Dose	Context
Clostridium difficile	200mg PO BID x 10 days (>12yr and >40kg); weight-based for younger	Pediatric Non-Severe (>6 months)

Special Populations

Pregnancy Rating

• Category B

Lactation risk

• Infant risk cannot be ruled out

Renal Dosing

• No adjustment

Hepatic Dosing

• Not established

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Bowel obstruction
• GI bleed

Common

• Abdominal pain, nausea/vomiting
• Anemia, neutropenia

Pharmacology

• Half-life: ~12h
• Metabolism: Intestinal
• Excretion: Fecal

Mechanism of Action

• Macrolide: inhibits RNA polymerases primarily against clostridia species

See Also

• C. diff
• Macrolides