Medical toxicology content overview

Overview

Principles of Toxicology

• Introduction to Medical Toxicology & History
• Principles of Toxicokinetics & Toxicodynamics (Absorption, Distribution, Metabolism, Excretion)
• Dose-Response Relationships and Thresholds (NOAEL, ED50, TD50)
• Molecular Mechanisms of Toxicity & Cellular Injury
• Principles of Mutagenesis, Carcinogenesis, and Epigenetics
• Reproductive and Developmental Toxicology (Teratogenesis)

Clinical Assessment and Management

• Initial Approach, Triage, and Stabilization of the Poisoned Patient
• Diagnostic Approach to the Unknown Overdose or Poisoning
• Gastrointestinal decontamination
  • Activated charcoal
  • Whole bowel irrigation
• Enhancement of drug elimination
  • Hemodialysis
  • Urinary alkalinization
• Antidotes and their general principles of use

Pharmaceutical and medication toxicities

• Analgesics
  • Acetaminophen toxicity
  • NSAID toxicity
  • Salicylate toxicity
• Cardiovascular Medications
  • Beta-blocker toxicity
  • Calcium channel blocker toxicity
  • Digoxin toxicity
• Psychopharmacologic agent toxicities
  • Serotonin syndrome
  • Antipsychotics
  • Tricyclic antidepressant toxicity
• Sedative, hypnotic, and alcohol toxicities
• Opioids and Withdrawal Management
  • Opioid toxicity
  • Opioid withdrawal
• Other
  • Theophylline toxicity
  • Local anesthetic systemic toxicity

Drugs of abuse

• Sympathomimetic toxicity
• Hallucinogen, designer drug, and club drug toxicities
  • Hallucinations
• Substance Use Disorders and Management of Chronic Poisoning

Drugs of abuse

• 25C-NBOMe‎
• Alcohol
• Amphetamines
• Bath salts
• Cocaine
• Difluoroethane
• Ecstasy
• Gamma hydroxybutyrate (GHB)
• Heroin
• Inhalant abuse
  • Hydrocarbon toxicity
  • Difluoroethane (electronics duster)
• Marijuana
• Kratom
• Phencyclidine (PCP)
• Psilocybin ("magic mushrooms")
• Synthetic cannabinoids
• Chloral hydrate
• Body packing

Household, Environmental, and Occupational Toxins

• Household Products, Caustics, and Hydrocarbons
  • Hydrocarbon toxicity
• Heavy metal toxicities
• Pesticides, Herbicides, and Rodenticides
  • Organophosphate toxicity
• Asphyxiants
  • Inhalation injury
  • Smoke inhalation injury
  • Carbon monoxide toxicity
  • Cyanide toxicity
  • Hydrogen sulfide
• Occupational Toxicology and Workplace Exposures

Natural Toxins, Envenomations, and Food Poisoning

• Plant Poisonings and Herbal Medications
• Fungi and mushroom toxicities
• Snakebites and spider envenomations
• Marine toxins, envenomations, and bites
• Bacterial Food Poisoning
  • Botulism
  • Bacterial gastroenteritis
  • Staphylococcal Enterotoxins

Special Topics in Toxicology

• Radiation and radiological emergencies
• Chemical, Biological, and Radiological (CBRN) Warfare Agents
  • Chemical weapons
  • Weapon of mass destruction
• Analytical and Forensic Toxicology (Drug Testing, Post-Mortem Toxicology)
• Pediatric Considerations in Poisoning
• Toxicology in Pregnancy and Lactation

Others

• Anticholinergic toxicity

See Also

• Toxicology (Main)